The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

The investigation of biological activities natural products, particularly considering the secondary metabolites, continuously receives attention. Urolithins, bioavailable metabolites ellagitannins, were shown to possess enzyme inhibitor, antioxidant, and anti-inflammatory compounds in scientific studies conducted last two decades. Regarding limited number related their antimicrobial activity, this study aimed synthesize major urolithins (Urolithin A B) concomitant methyl ether derivatives screen antibacterial activity against some Gram-positive Gram-negative bacteria. In parallel synergistic antagonist properties also analyzed presence reference beta-lactam antibiotics. results displayed improvable characteristics urolithin scaffold be employed antibiotic drug design studies. addition, effect on action standard molecules pointed out compound-specific title molecules.